Paul De Koninck

Paul De Koninck

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Associate Professor, Département de Biochimie, Microbiologie et Bio-Informatique, Université Laval, 2006-now

Assistant Professor, Département de Biochimie et Microbiologie, Université Laval, 2001-2006


Director, Graduate Program in Biophotonics, Université Laval, 2008-now


  • Post-doctoral training, Stanford University, 1995-2001
  • Ph.D. - Neurobiology, McGill University, 1995




Tardif, Christian, Gabriel Nadeau, Simon Labrecque, Daniel Côté, Flavie Lavoie-Cardinal, and Paul De Koninck. "Fluorescence lifetime imaging nanoscopy for measuring Förster resonance energy transfer in cellular nanodomains." Neurophotonics 6, no. 1 (2019): 015002.
Lavoie-Cardinal, Flavie, Charleen Salesse, Pierre-Luc Ayotte-Nadeau, and Paul De Koninck. "Nanoparticle-Assisted Localized Optical Stimulation of Cultured Neurons." In Use of Nanoparticles in Neuroscience, edited by Fidel Santamaria and Xomalin G. Peralta, 15-23. New York, NY: Springer New York, 2018.
Durand, Audrey, Theresa Wiesner, Marc-André Gardner, Louis-Émile Robitaille, Anthony Bilodeau, Christian Gagné, Paul De Koninck, and Flavie Lavoie-Cardinal. "A machine learning approach for online automated optimization of super-resolution optical microscopy." Nat Commun 9, no. 1 (2018): 5247.
Glasgow, Stephen D., Simon Labrecque, Ian V. Beamish, Sarah Aufmkolk, Julien Gibon, Dong Han, Stephanie N. Harris, Paul Dufresne, Paul W. Wiseman, Anne R McKinney et al. "Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus." Cell Rep 25, no. 1 (2018): 168-182.e6.
Malvaut, Sarah, Simona Gribaudo, Delphine Hardy, Linda Suzanne David, Laura Daroles, Simon Labrecque, Marie-Anne Lebel-Cormier, Zayna Chaker, Daniel Côté, Paul De Koninck et al. "CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior." Curr Biol 27, no. 21 (2017): 3315-3329.e6.
Labrecque, Simon, Jean-Philippe Sylvestre, Stephane Marcet, Francesca Mangiarini, Brice Bourgoin, Marc Verhaegen, Sébastien Blais-Ouellette, and Paul De Koninck. "Hyperspectral multiplex single-particle tracking of different receptor subtypes labeled with quantum dots in live neurons." J Biomed Opt 21, no. 4 (2016): 46008.
Fatimy, Rachid El, Laetitia Davidovic, Sandra Tremblay, Xavier Jaglin, Alain Y. Dury, Claude Robert, Paul De Koninck, and Edouard W. Khandjian. "Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules." PLoS Genet 12, no. 7 (2016): e1006192.
Lavoie-Cardinal, Flavie, Charleen Salesse, Éric Bergeron, Michel Meunier, and Paul De Koninck. "Gold nanoparticle-assisted all optical localized stimulation and monitoring of Ca²⁺ signaling in neurons." Sci Rep 6 (2016): 20619.
Kaczmarczyk, Lech, Étienne Labrie-Dion, Kapil Sehgal, Marc Sylvester, Magdalena Skubal, Michele Josten, Christian Steinhäuser, Paul De Koninck, and Martin Theis. "New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of CPEB3 Protein." PLoS One 11, no. 2 (2016): e0150000.
Gross, Garrett G., Christoph Straub, Jimena Perez-Sanchez, William P. Dempsey, Jason A. Junge, Richard W. Roberts, Le A. Trinh, Scott E. Fraser, Yves De Koninck, Paul De Koninck et al. "An E3-ligase-based method for ablating inhibitory synapses." Nat Methods (2016).
Doré, Kim, Simon Labrecque, Christian Tardif, and Paul De Koninck. "FRET-FLIM investigation of PSD95-NMDA receptor interaction in dendritic spines; control by calpain, CaMKII and Src family kinase." PLoS One 9, no. 11 (2014): e112170.
Zou, Ming, Paul De Koninck, Rachael L. Neve, and Rainer W. Friedrich. "Fast gene transfer into the adult zebrafish brain by herpes simplex virus 1 (HSV-1) and electroporation: methods and optogenetic applications." Front Neural Circuits 8 (2014): 41.
Dury, Alain Y., Rachid El Fatimy, Sandra Tremblay, Timothy M. Rose, Jocelyn Côté, Paul De Koninck, and Edouard W. Khandjian. "Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies." PLoS Genet 9, no. 10 (2013): e1003890.
Flynn, Robyn, Étienne Labrie-Dion, Nikolas Bernier, Michael A. Colicos, Paul De Koninck, and Gerald W. Zamponi. "Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα." PLoS One 7, no. 7 (2012): e41185.
Fatimy, Rachid El, Sandra Tremblay, Alain Y. Dury, Samuel Solomon, Paul De Koninck, John W. Schrader, and Edouard W. Khandjian. "Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected]." PLoS One 7, no. 6 (2012): e39338.
El Gaamouch, Farida, Alain Buisson, Olivier Moustié, Mado Lemieux, Simon Labrecque, Bruno Bontempi, Paul De Koninck, and Olivier Nicole. "Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity." J Neurosci 32, no. 31 (2012): 10767-79.
Lemieux, Mado, Simon Labrecque, Christian Tardif, Étienne Labrie-Dion, Eric Lebel, and Paul De Koninck. "Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses." J Cell Biol 198, no. 6 (2012): 1055-73.
Laffray, Sophie, Stéphane Pagès, Hugues Dufour, Paul De Koninck, Yves De Koninck, and Daniel Côté. "Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue." PLoS One 6, no. 5 (2011): e19928.
Therrien, O D., B Aubé, Stéphane Pagès, Paul De Koninck, and D Côté. "Wide-field multiphoton imaging of cellular dynamics in thick tissue by temporal focusing and patterned illumination." Biomed Opt Express 2, no. 3 (2011): 696-704.
Pagès, Stéphane, Daniel Côté, and Paul De Koninck. "Optophysiological approach to resolve neuronal action potentials with high spatial and temporal resolution in cultured neurons." Front Cell Neurosci 5 (2011): 20.
Nault, Francine, and Paul De Koninck. "Dissociated Hippocampal Cultures." In Protocols for Neural Cell Culture: Fourth Edition, edited by Laurie C. Doering, 137-159. Totowa, NJ: Humana Press, 2010.
Parys, B, A Côté, V Gallo, Paul De Koninck, and A Sík. "Intercellular calcium signaling between astrocytes and oligodendrocytes via gap junctions in culture." Neuroscience 167, no. 4 (2010): 1032-43.
Opazo, Patricio, Simon Labrecque, Cezar M. Tigaret, Arnaud Frouin, Paul W. Wiseman, Paul De Koninck, and Daniel Choquet. "CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin." Neuron 67, no. 2 (2010): 239-52.
Pi, Hyun Jae, Nikolai Otmakhov, David Lemelin, Paul De Koninck, and John Lisman. "Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation." J Neurosci 30, no. 26 (2010): 8704-9.
Pi, Hyun Jae, Nikolai Otmakhov, Farida El Gaamouch, David Lemelin, Paul De Koninck, and John Lisman. "CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action." Proc Natl Acad Sci U S A 107, no. 32 (2010): 14437-42.
Heinze, Katrin G., Santiago Costantino, Paul De Koninck, and Paul W. Wiseman. "Beyond photobleaching, laser illumination unbinds fluorescent proteins." J Phys Chem B 113, no. 15 (2009): 5225-33.
De Koninck, Paul, Simon Labrecque, Colin D. Heyes, and Paul W. Wiseman. "Probing synaptic signaling with quantum dots." HFSP J 1, no. 1 (2007): 5-10.
Smith, Benjamin A., Hugo Roy, Paul De Koninck, Peter Grütter, and Yves De Koninck. "Dendritic spine viscoelasticity and soft-glassy nature: balancing dynamic remodeling with structural stability." Biophys J 92, no. 4 (2007): 1419-30.
Taylor, David M., Paul De Koninck, Sandra Minotti, and Heather D. Durham. "Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells." Mol Cell Neurosci 34, no. 1 (2007): 20-33.
Bayer, K Ulrich, Eric Lebel, Greg L. McDonald, Heather O'Leary, Howard Schulman, and Paul De Koninck. "Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B." J Neurosci 26, no. 4 (2006): 1164-74.
Davidovic, Laetitia, Sandra Tremblay, Maud Gravel, Paul De Koninck, and Edward W. Miky Khandjian. "[The fragile X syndrome: one protein missing and 1001 disoriented mRNAs]." Med Sci (Paris) 22, no. 1 (2006): 41-6.
Thibaud, C, V Koubassov, Paul De Koninck, S L. Chin, and Y De Koninck. "Destruction of polymer growth substrates for cell cultures in two-photon microscopy." J Microsc 220, no. Pt 2 (2005): 120-7.
Hudmon, Andy, Eric Lebel, Hugo Roy, Attila Sik, Howard Schulman, Neal M Waxham, and Paul De Koninck. "A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association." J Neurosci 25, no. 30 (2005): 6971-83.
Costantino, Santiago, Katrin G. Heinze, Oscar E. Martínez, Paul De Koninck, and Paul W. Wiseman. "Two-photon fluorescent microlithography for live-cell imaging." Microsc Res Tech 68, no. 5 (2005): 272-6.
Dupont, Geneviève, Gérald Houart, and Paul De Koninck. "Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model." Cell Calcium 34, no. 6 (2003): 485-97.
Coull, Jeffrey A. M., Dominic Boudreau, Karine Bachand, Steven A. Prescott, Francine Nault, Attila Sik, Paul De Koninck, and Yves De Koninck. "Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain." Nature 424, no. 6951 (2003): 938-42.
Bayer, K Ulrich, Paul De Koninck, and Howard Schulman. "Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations." EMBO J 21, no. 14 (2002): 3590-7.
Bayer, K Ulrich, Paul De Koninck, A S. Leonard, J W. Hell, and H Schulman. "Interaction with the NMDA receptor locks CaMKII in an active conformation." Nature 411, no. 6839 (2001): 801-5.
De Koninck, Paul, and H Schulman. "Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations." Science 279, no. 5348 (1998): 227-30.
Mandelzys, A, Paul De Koninck, and E Cooper. "Agonist and toxin sensitivities of ACh-evoked currents on neurons expressing multiple nicotinic ACh receptor subunits." J Neurophysiol 74, no. 3 (1995): 1212-21.
De Koninck, Paul, S Carbonetto, and E Cooper. "NGF induces neonatal rat sensory neurons to extend dendrites in culture after removal of satellite cells." J Neurosci 13, no. 2 (1993): 577-85.


Our research endeavors are made possible by the following agencies:

Canadian Institutes of Health Research - Instituts de recherche en santé du Canada Fonds de recherche du Québec – Nature et technologies (FRQNT)Fonds de la recherche en santé du Québec   Natural Sciences and Engineering Research Council of Canada (NSERC) - Conseil de recherche en sciences naturelles et en génie du Canada (CRSNG)innovation.caHuman Frontier Science ProgramCanada First Research Excellence FundSentinelle Nord