Paul De Koninck

Paul De Koninck

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Associate Professor, Département de Biochimie, Microbiologie et Bio-Informatique, Université Laval, 2006-now

Assistant Professor, Département de Biochimie et Microbiologie, Université Laval, 2001-2006


Director, Graduate Program in Biophotonics, Université Laval, 2008-now


  • Post-doctoral training, Stanford University, 1995-2001
  • Ph.D. - Neurobiology, McGill University, 1995




Doré, Kim, Simon Labrecque, Christian Tardif, and Paul De Koninck. "FRET-FLIM investigation of PSD95-NMDA receptor interaction in dendritic spines; control by calpain, CaMKII and Src family kinase." PLoS One 9, no. 11 (2014): e112170.
Zou, Ming, Paul De Koninck, Rachael L. Neve, and Rainer W. Friedrich. "Fast gene transfer into the adult zebrafish brain by herpes simplex virus 1 (HSV-1) and electroporation: methods and optogenetic applications." Front Neural Circuits 8 (2014): 41.
Dury, Alain Y., Rachid El Fatimy, Sandra Tremblay, Timothy M. Rose, Jocelyn Côté, Paul De Koninck, and Edouard W. Khandjian. "Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies." PLoS Genet 9, no. 10 (2013): e1003890.
Lemieux, Mado, Simon Labrecque, Christian Tardif, Étienne Labrie-Dion, Eric Lebel, and Paul De Koninck. "Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses." J Cell Biol 198, no. 6 (2012): 1055-73.
Flynn, Robyn, Étienne Labrie-Dion, Nikolas Bernier, Michael A. Colicos, Paul De Koninck, and Gerald W. Zamponi. "Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα." PLoS One 7, no. 7 (2012): e41185.
Fatimy, Rachid El, Sandra Tremblay, Alain Y. Dury, Samuel Solomon, Paul De Koninck, John W. Schrader, and Edouard W. Khandjian. "Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected]." PLoS One 7, no. 6 (2012): e39338.
El Gaamouch, Farida, Alain Buisson, Olivier Moustié, Mado Lemieux, Simon Labrecque, Bruno Bontempi, Paul De Koninck, and Olivier Nicole. "Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity." J Neurosci 32, no. 31 (2012): 10767-79.
Pagès, Stéphane, Daniel Côté, and Paul De Koninck. "Optophysiological approach to resolve neuronal action potentials with high spatial and temporal resolution in cultured neurons." Front Cell Neurosci 5 (2011): 20.
Laffray, Sophie, Stéphane Pagès, Hugues Dufour, Paul De Koninck, Yves De Koninck, and Daniel Côté. "Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue." PLoS One 6, no. 5 (2011): e19928.
Therrien, O D., B Aubé, S Pagès, Paul De Koninck, and D Côté. "Wide-field multiphoton imaging of cellular dynamics in thick tissue by temporal focusing and patterned illumination." Biomed Opt Express 2, no. 3 (2011): 696-704.
Pi, Hyun Jae, Nikolai Otmakhov, Farida El Gaamouch, David Lemelin, Paul De Koninck, and John Lisman. "CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action." Proc Natl Acad Sci U S A 107, no. 32 (2010): 14437-42.
Parys, B, A Côté, V Gallo, Paul De Koninck, and A Sík. "Intercellular calcium signaling between astrocytes and oligodendrocytes via gap junctions in culture." Neuroscience 167, no. 4 (2010): 1032-43.
Opazo, Patricio, Simon Labrecque, Cezar M. Tigaret, Arnaud Frouin, Paul W. Wiseman, Paul De Koninck, and Daniel Choquet. "CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin." Neuron 67, no. 2 (2010): 239-52.
Pi, Hyun Jae, Nikolai Otmakhov, David Lemelin, Paul De Koninck, and John Lisman. "Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation." J Neurosci 30, no. 26 (2010): 8704-9.
Heinze, Katrin G., Santiago Costantino, Paul De Koninck, and Paul W. Wiseman. "Beyond photobleaching, laser illumination unbinds fluorescent proteins." J Phys Chem B 113, no. 15 (2009): 5225-33.
De Koninck, Paul, Simon Labrecque, Colin D. Heyes, and Paul W. Wiseman. "Probing synaptic signaling with quantum dots." HFSP J 1, no. 1 (2007): 5-10.
Smith, Benjamin A., Hugo Roy, Paul De Koninck, Peter Grütter, and Yves De Koninck. "Dendritic spine viscoelasticity and soft-glassy nature: balancing dynamic remodeling with structural stability." Biophys J 92, no. 4 (2007): 1419-30.
Taylor, David M., Paul De Koninck, Sandra Minotti, and Heather D. Durham. "Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells." Mol Cell Neurosci 34, no. 1 (2007): 20-33.
Bayer, K Ulrich, Eric Lebel, Greg L. McDonald, Heather O'Leary, Howard Schulman, and Paul De Koninck. "Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B." J Neurosci 26, no. 4 (2006): 1164-74.
Davidovic, Laetitia, Sandra Tremblay, Maud Gravel, Paul De Koninck, and Edward W. Miky Khandjian. "[The fragile X syndrome: one protein missing and 1001 disoriented mRNAs]." Med Sci (Paris) 22, no. 1 (2006): 41-6.
Thibaud, C, V Koubassov, Paul De Koninck, S L. Chin, and Y De Koninck. "Destruction of polymer growth substrates for cell cultures in two-photon microscopy." J Microsc 220, no. Pt 2 (2005): 120-7.
Hudmon, Andy, Eric Lebel, Hugo Roy, Attila Sik, Howard Schulman, Neal M Waxham, and Paul De Koninck. "A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association." J Neurosci 25, no. 30 (2005): 6971-83.
Costantino, Santiago, Katrin G. Heinze, Oscar E. Martínez, Paul De Koninck, and Paul W. Wiseman. "Two-photon fluorescent microlithography for live-cell imaging." Microsc Res Tech 68, no. 5 (2005): 272-6.
Dupont, Geneviève, Gérald Houart, and Paul De Koninck. "Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model." Cell Calcium 34, no. 6 (2003): 485-97.
Coull, Jeffrey A. M., Dominic Boudreau, Karine Bachand, Steven A. Prescott, Francine Nault, Attila Sik, Paul De Koninck, and Yves De Koninck. "Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain." Nature 424, no. 6951 (2003): 938-42.
Bayer, K Ulrich, Paul De Koninck, and Howard Schulman. "Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations." EMBO J 21, no. 14 (2002): 3590-7.
Bayer, K Ulrich, Paul De Koninck, A S. Leonard, J W. Hell, and H Schulman. "Interaction with the NMDA receptor locks CaMKII in an active conformation." Nature 411, no. 6839 (2001): 801-5.
De Koninck, Paul, and H Schulman. "Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations." Science 279, no. 5348 (1998): 227-30.
Mandelzys, A, Paul De Koninck, and E Cooper. "Agonist and toxin sensitivities of ACh-evoked currents on neurons expressing multiple nicotinic ACh receptor subunits." J Neurophysiol 74, no. 3 (1995): 1212-21.
De Koninck, Paul, S Carbonetto, and E Cooper. "NGF induces neonatal rat sensory neurons to extend dendrites in culture after removal of satellite cells." J Neurosci 13, no. 2 (1993): 577-85.


Our research endeavors are made possible by the following agencies:

Canadian Institutes of Health Research - Instituts de recherche en santé du Canada Fonds de recherche du Québec – Nature et technologies (FRQNT)Fonds de la recherche en santé du Québec NARSAD Natural Sciences and Engineering Research Council of Canada (NSERC) - Conseil de recherche en sciences naturelles et en génie du Canada (CRSNG)innovation.caHuman Frontier Science Program